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Nonclinical Drug Development (Senior) Scientist

Nonclinical Drug Development (Senior) Scientist

ProQR TherapeuticsLeiden, Zuid-Holland, Netherlands
25 dagen geleden
Functieomschrijving

Nonclinical Drug Development (Senior) Scientist

ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands and Cambridge, Massachusetts, USA. ProQR is focused on the development of life-changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 150+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. Our proprietary Axiomer RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells' own editing machinery.

ProQR is currently recruiting a Nonclinical Drug Development Expert (Scientist / Senior Scientist) with expertise in Toxicology and ADME to join the Translational Development team, which works collaboratively in Discovery and Clinical Development on in vivo pharmacology studies, in vitro and in vivo safety studies, bioanalysis, pharmacokinetics, and biomarkers. In your role, you will report to the VP Toxicology and DMPK / Head Preclinical Team.

The role :

ProQR is looking for an all-around nonclinical subject matter expert responsible for the design and monitoring of in vivo studies (through selected vendors), evaluation of data, and development of PKPD / disease models in our research and development programs. Studies will range from pharmacology to toxicology (ICH / GLP). The successful candidate is an enthusiastic and creative team player who will work closely with other colleagues in an interdisciplinary team environment to progress the translational science in ProQR’s programs.

Key Responsibilities :

  • Work with project teams to develop nonclinical packages that support the progression of candidates from lead selection to the clinic.
  • Plan, execute, and oversee the conduct of external studies (including GLP studies) according to agreed timelines, including deriving cost estimates and requesting slots at contract research organizations (CROs).
  • Review protocols and study reports, with a keen eye on data analysis and interpretation.
  • Generate PK, PD, and safety datasets.
  • Integrate data analysis across studies and multiple disciplines.
  • Ensure timeline and budget compliance.

Required qualifications :

  • Typically, the candidate will have at least a PhD or equivalent, or an MSc with 5 years of experience in a relevant field.
  • Knowledge and experience in pharmacology, ADME, and / or Toxicology in drug development is essential.
  • Experience with contributions to regulatory documents and / or working with PK software is preferred.
  • Experience with RNA therapeutics or other innovative technologies in drug development is preferred.
  • Team player with a hands-on and can-do mentality.
  • Flexible attitude, able to work in a fast-paced and dynamic environment.
  • Proactive and pragmatic self-starter, with a result-oriented & problem-solving mindset.

    • ProQR as an employer :

    As an employer, we believe in the value of a diverse workforce and encourage personal and professional development. We are committed to creating an inclusive culture where everyone can be valued for who they are, and individual differences and contributions are recognized and valued.

    We offer an exciting and innovative working environment with the following benefits :

  • An annual performance bonus.
  • Stock options.
  • A premium-free pension plan.
  • A commuting allowance.
  • Unlimited (un)healthy snacks and drinks.
  • Employee events (boot camp, Hipster café, and other social events).

    • If you think you can contribute to achieving our mission, we look forward to receiving your application by filling out our application form.

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