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Associate Researcher Oligonucleotide Chemistry

Associate Researcher Oligonucleotide Chemistry

ProQR TherapeuticsLeiden, Zuid-Holland, Netherlands
3 dagen geleden
Functieomschrijving

Department CMC / Development

ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands and Cambridge, Massachusetts, USA. ProQR is focused on the development of life-changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 150+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. Our proprietary Axiomer RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cell's own editing machinery. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases.

Our Chemistry, Manufacturing and Control (CMC) department is currently looking for an Associate Researcher Oligonucleotide Chemistry (Full-time) to join our team.

We are looking for candidates with a passion for working in a chemical laboratory; this role would suit a recent graduate with a background in chemistry or related disciplines. The CMC department has a central role within the ProQR Therapeutics organization, developing, manufacturing, and characterizing oligonucleotides and therapeutic formulations for research, clinical development, and commercialization.

The Role

The Associate Researcher will support the in-house lab activities of the Drug Substance & Chemistry team, which is part of the CMC department. The successful candidate will work closely with other researchers / scientists in an interdisciplinary team environment to help with all activities related to the production of oligonucleotides, which includes :

  • Manufacturing of oligonucleotides by performing all stages of the process, such as synthesis, cleavage & deprotection, and purification.
  • Proper documentation and accurate record keeping of experimental data.
  • Execution of analytical tests (HPLC, UV-Vis, and mass spectrometry).
  • Support preparation of technical protocols and reports.
  • Preparation or revision of standard operating procedures (SOPs).
  • Support general lab activities such as equipment maintenance and inventory management.

We expect our Associate Researcher to have :

  • An MLO or HLO degree in Organic Chemistry, Analytical Chemistry, Biochemistry, Biopharmaceutical Sciences, or a related scientific discipline with up to 2 years of industry experience.
  • Strong laboratory skills and a high degree of attention to detail.
  • Good understanding of, and hands-on experience with, analytical techniques such as HPLC, LCMS, and UV-Vis spectroscopy.
  • Proficiency in spoken and written English.
  • A responsible person with a proactive attitude who can work independently.
  • Flexibility, analytical skills, and well-organized.
  • A team player.

    • We would like our Associate Researcher to have :

  • Knowledge of oligonucleotide (or peptide) manufacturing (synthesis, purification, and / or analysis) is a plus.
  • Enjoy challenging situations and have the flexibility to work in a dynamic and fast-moving environment.

    • ProQR as an employer

    As an employer, we believe in the value of a diverse workforce where people from various backgrounds are encouraged to develop personally and professionally. We are committed to creating an inclusive culture where everyone can be valued for who they are, and individual differences are recognized and valued.

    We offer an exciting and innovative working environment in a committed organization, with the following benefits :

  • An annual performance bonus.
  • Stock options.
  • A premium-free pension plan.
  • A commuting allowance.
  • Unlimited (un)healthy snacks and drinks.
  • Employee events (boot camp, Rebel Café, and other social events).

    • Do you think you can contribute to achieving our mission? If so, we’re looking forward to receiving your application by filling out our application form.

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